Figure 1: Alterations in DNA methylation patterns change expression of certain genes in PCa. Both DNA (a) hypermethylation and (b) hypomethylation are found in cancer cells. Effects of these changes in DNA methylation profiles on gene expression, chromatin structure, or transcriptional regulatory network are demonstrated as what the zoomed-in areas depicted. Genes that are transcriptionally modulated by each specific mechanism of DNA methylation in PCa are listed, categorized by the biological functions each representative gene may be involved in. PCa: prostate cancer; green bars: sites in unmethylated states; red bars: methylated sites.