Close
  Indian J Med Microbiol
 

Figure 2: Factors affecting disorder-order transition of the SHRs' AF1/NTD. (a) As such NTD/AF1 exists in an ID conformation compared to well-ordered DBD and LBD. (b) Under the influence of factors shown, NTD/AF1 undergoes disorder-order transition, resulting into the folding of NTD/AF1. (c) In this conformation, AF1/NTD surfaces are well suited for its interaction with specific coactivators, binding of which further influences the conformation of NTD/AF1 and facilitates the formation of AF1-coactitors assembly in a promoter-specific manner to regulate the expression of target gene(s). (d) In cells/tissues where there is an excess level of expression of an AF1 binding partner (e.g., proteins from basal transcription machinery), AF1 can directly interact with it and regulate the expression of target gene(s).

Figure 2: Factors affecting disorder-order transition of the SHRs' AF1/NTD. (a) As such NTD/AF1 exists in an ID conformation compared to well-ordered DBD and LBD. (b) Under the influence of factors shown, NTD/AF1 undergoes disorder-order transition, resulting into the folding of NTD/AF1. (c) In this conformation, AF1/NTD surfaces are well suited for its interaction with specific coactivators, binding of which further influences the conformation of NTD/AF1 and facilitates the formation of AF1-coactitors assembly in a promoter-specific manner to regulate the expression of target gene(s). (d) In cells/tissues where there is an excess level of expression of an AF1 binding partner (e.g., proteins from basal transcription machinery), AF1 can directly interact with it and regulate the expression of target gene(s).