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  Indian J Med Microbiol
 

Figure 1: Topology of apoptosis regulatory network. Network of antiapoptotic signalling pathways where active PI3-kinase, receptor tyrosine kinases, and G-protein coupled receptors converge on BAD and Mcl-1. Expression pattern of the Bcl2 family of proteins determines whether BAD dephosphorylation and loss of Mcl-1 will induce rapid apoptosis.

Figure 1: Topology of apoptosis regulatory network. Network of antiapoptotic signalling pathways where active PI3-kinase, receptor tyrosine kinases, and G-protein coupled receptors converge on BAD and Mcl-1. Expression pattern of the Bcl2 family of proteins determines whether BAD dephosphorylation and loss of Mcl-1 will induce rapid apoptosis.