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  Indian J Med Microbiol
 

Figure 1: Enhancing reprogramming efficiency with TAD-TF chimeras. (a) Domain structure of VP16, MyoD and YAP from which TADs were derived. (b) Domain structure of chimeric Oct4-TAD proteins demonstrated to potently enhance the reprogramming of somatic cells to iPSCs.93,97,103 YAP1 was drawn according to Uniprot-ID P46938 and VP16 and MyoD according to Hirai et al.,99 2010. TAD: transactivation domain; bHLH: basic helix-loop-helix domain; POU: Pit1-Oct-Unc-86 related domain; TEAD-IA: interaction region with the TF TEAD; TFs: transcription factors; Oct4: octamer binding protein 4; iPSCs: induce pluripotent stem cells; VP16: viral protein 16; YAP: yes-associated protein.

Figure 1: Enhancing reprogramming efficiency with TAD-TF chimeras. (a) Domain structure of VP16, MyoD and YAP from which TADs were derived. (b) Domain structure of chimeric Oct4-TAD proteins demonstrated to potently enhance the reprogramming of somatic cells to iPSCs.93,97,103 YAP1 was drawn according to Uniprot-ID P46938 and VP16 and MyoD according to Hirai <i>et al</i>.,99 2010. TAD: transactivation domain; bHLH: basic helix-loop-helix domain; POU: Pit1-Oct-Unc-86 related domain; TEAD-IA: interaction region with the TF TEAD; TFs: transcription factors; Oct4: octamer binding protein 4; iPSCs: induce pluripotent stem cells; VP16: viral protein 16; YAP: yes-associated protein.