Asian Journal of Andrology

INVITED ORIGINAL ARTICLE
Year
: 2016  |  Volume : 18  |  Issue : 5  |  Page : 662--672

Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer


Kevin S Landau1, Insung Na1, Ryan O Schenck1, Vladimir N Uversky2 
1 Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
2 Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia

Correspondence Address:
Dr. Vladimir N Uversky
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; USF Health Byrd Alzheimer«SQ»s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia

Prostatic diseases such as prostate cancer and benign prostatic hyperplasia are highly prevalent among men. The number of studies focused on the abundance and roles of intrinsically disordered proteins in prostate cancer is rather limited. The goal of this study is to analyze the prevalence and degree of disorder in proteins that were previously associated with the prostate cancer pathogenesis and to compare these proteins to the entire human proteome. The analysis of these datasets provides means for drawing conclusions on the roles of disordered proteins in this common male disease. We also hope that the results of our analysis can potentially lead to future experimental studies of these proteins to find novel pathways associated with this disease.


How to cite this article:
Landau KS, Na I, Schenck RO, Uversky VN. Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer.Asian J Androl 2016;18:662-672


How to cite this URL:
Landau KS, Na I, Schenck RO, Uversky VN. Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer. Asian J Androl [serial online] 2016 [cited 2022 Oct 1 ];18:662-672
Available from: https://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=5;spage=662;epage=672;aulast=Landau;type=0