Asian Journal of Andrology

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 17  |  Issue : 3  |  Page : 503--507

PSA density improves the rate of prostate cancer detection in Chinese men with a PSA between 2.5-10.0 ng ml -1 and 10.1-20.0 ng ml -1 : a multicenter study


Yu-Rong Lin1, Xing-Hua Wei2, Matthew Uhlman3, Xuan-Ting Lin2, Si-Feng Wu2, Peng-Fei Diao2, Hai-Qing Xie2, Ke-Ji Xie2, Ping Tang2 
1 Department of Urology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180; Department of Urology, Jieyang People's Hospital, Jieyang 522000, China
2 Department of Urology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China
3 Department of Urology, University of Iowa, Iowa City, IA 52242, USA

Correspondence Address:
Ping Tang
Department of Urology, Guangzhou First PeopleSQs Hospital, Guangzhou Medical University, Guangzhou 510180
China

Chinese men should have a higher prostate-specific antigen (PSA) DQgray zoneDQ than the traditional value of 2.5-10.0 ng ml−1 since the incidence of prostate cancer (PCa) in Chinese men is relative low. We hypothesized that PSA density (PSAD) could improve the rate of PCa detection in Chinese men with a PSA higher than the traditional PSA DQgray zone.DQ A total of 461 men with a PSA between 2.5 and 20.0 ng ml−1 , who had undergone prostatic biopsy at two Chinese centers were included in the analysis. The men were then further divided into groups with a PSA between 2.5-10.0 ng ml−1 and 10.1-20.0 ng ml−1 . Receiver operating characteristic (ROC) curve was used to evaluate the efficacy of PSA and PSAD for the diagnosis of PCa. In men with a PSA of 2.5-10.0 ng ml−1 or 10.1-20.0 ng ml−1 , the areas under the ROC curve were higher for PSAD than for PSA. This was consistent across both centers and the cohort overall. When the entire cohort was considered, the optimal PSAD cut-off for predicting PCa in men with a PSA of 2.5-10.0 ng ml−1 was 0.15 ng ml−1 ml−1 , with a sensitivity of 64.4% and specificity of 64.6%. The optimal cut-off for PSAD in men with a PSA of 10.1-20.0 ng ml−1 was 0.33 ng ml−1 ml−1 , with a sensitivity of 60.3% and specificity of 82.7%. PSAD can improve the effectiveness for PCa detection in Chinese men with a PSA of 2.5-10.0 ng ml−1 (traditional Western PSA DQgray zoneDQ) and 10.1-20.0 ng ml−1 (Chinese PSA DQgray zoneDQ).


How to cite this article:
Lin YR, Wei XH, Uhlman M, Lin XT, Wu SF, Diao PF, Xie HQ, Xie KJ, Tang P. PSA density improves the rate of prostate cancer detection in Chinese men with a PSA between 2.5-10.0 ng ml -1 and 10.1-20.0 ng ml -1 : a multicenter study.Asian J Androl 2015;17:503-507


How to cite this URL:
Lin YR, Wei XH, Uhlman M, Lin XT, Wu SF, Diao PF, Xie HQ, Xie KJ, Tang P. PSA density improves the rate of prostate cancer detection in Chinese men with a PSA between 2.5-10.0 ng ml -1 and 10.1-20.0 ng ml -1 : a multicenter study. Asian J Androl [serial online] 2015 [cited 2022 Aug 9 ];17:503-507
Available from: https://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=3;spage=503;epage=507;aulast=Lin;type=0