Asian Journal of Andrology

INVITED REVIEW
Year
: 2015  |  Volume : 17  |  Issue : 3  |  Page : 347--354

Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation


Xing-Xing Mei1, Jian Wang1, Ji Wu2 
1 Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Bio X Institutes, Shanghai Jiao Tong University, Shanghai 200240, China
2 Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Bio X Institutes, Shanghai Jiao Tong University, Shanghai 200240; Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan 750004; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China

Correspondence Address:
Ji Wu
Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Bio X Institutes, Shanghai Jiao Tong University, Shanghai 200240; Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan 750004; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025
China

Spermatogonial stem cells (SSCs), the stem cells responsible for male fertility, are one of a small number of cells with the abilities of both self-renewal and generation of large numbers of haploid cells. Technology improvements, most importantly, transplantation assays and in vitro culture systems have greatly expanded our understanding of SSC self-renewal and differentiation. Many important molecules crucial for the balance between self-renewal and differentiation have been recently identified although the exact mechanism(s) remain largely undefined. In this review, we give a brief introduction to SSCs, and then focus on extrinsic and intrinsic factors controlling SSCs self-renewal and differentiation.


How to cite this article:
Mei XX, Wang J, Wu J. Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation.Asian J Androl 2015;17:347-354


How to cite this URL:
Mei XX, Wang J, Wu J. Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation. Asian J Androl [serial online] 2015 [cited 2022 Aug 13 ];17:347-354
Available from: https://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=3;spage=347;epage=354;aulast=Mei;type=0