ORIGINAL ARTICLE
Ahead of Print

An examination of predictive markers for successful sperm extraction procedures: a linear model and systematic review


1 Department of Urology, Medical University of South Carolina, Charleston, SC 29425, USA
2 Department of Healthcare Leadership and Management, Medical University of South Carolina, Charleston, SC 29425, USA
3 Department of Urology, University of North Carolina, Chapel Hill, NC 27514, USA

Correspondence Address:
Marc Rogers,
Department of Urology, University of North Carolina, Chapel Hill, NC 27514
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aja202221

The authors performed a comprehensive review of current literature to create a model comparing commonly evaluated variables in male factor infertility, for example, follicle-stimulating hormone (FSH), testicular volume (TV), and testosterone (T), to better predict sperm retrieval rate (SRR). Twenty-nine studies were included, 9 with data on conventional testicular sperm extraction (cTESE) for a total of 1227 patients and 20 studies including data on microdissection testicular sperm extraction (mTESE) for a total of 4760 patients. A weighted-means value of SRR, FSH, T, and TV was created, and a weighted linear regression was then used to describe associations among SRR, type of procedure, FSH, T, and TV. In this study, weighted-means values demonstrated mTESE to be superior to cTESE with an SRR of 51.9% vs 40.1%. Multiple weighted linear regressions were created to describe associations among SRR, procedure type, FSH, T, and TV. The models showed that for every 1.19 mIU ml−1 increase in FSH, there would be a significant decrease in SRR by 1.0%. Seeking to create a more clinically relevant model, FSH values were then divided into normal, moderate elevation, and significant elevation categories (FSH <10 mIU ml−1, 10–19 mIU ml−1, and >20 mIU ml−1, respectively). For an index patient undergoing cTESE, the retrieval rates would be 57.1%, 44.3%, and 31.2% for values normal, moderately elevated, and significantly elevated, respectively. In conclusion, in a large meta-analysis, mTESE was shown to be more successful than cTESE for sperm retrievals. FSH has an inverse relationship to SRR in retrieval techniques and can alone be predictive of cTESE SRR.


[FULL TEXT] [PDF]
Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Major N
    -  Edwards K R
    -  Simpson K
    -  Rogers M
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed409    
    PDF Downloaded19    

Recommend this journal