ORIGINAL ARTICLE
Ahead of Print

Free PSA performs better than total PSA in predicting prostate volume in Chinese men with PSA levels of 2.5–9.9 ng ml−1


1 Department of Urology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
2 Department of Urology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510180, China
3 Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital, Guangzhou 510440, China
4 Department of Urology, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Foshan 528253, China
5 Department of Urology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-Sen University, Jiangmen 529099, China

Correspondence Address:
Ma-Ping Huang,
Department of Urology, The First Affiliated Hospital of Jinan University, Guangzhou 510630; Department of Urology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510180; Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital, Guangzhou 510440
China
Ping Tang,
Department of Urology, The First Affiliated Hospital of Jinan University, Guangzhou 510630; Department of Urology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510180
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aja202217

This study investigated whether free prostate-specific antigen (fPSA) performs better than total PSA (tPSA) in predicting prostate volume (PV) in Chinese men with different PSA levels. A total of 5463 men with PSA levels of <10 ng ml−1 and without prostate cancer diagnosis were included in this study. Patients were classified into four groups: PSA <2.5 ng ml−1, 2.5–3.9 ng ml−1, 4.0–9.9 ng ml−1, and 2.5–9.9 ng ml−1. Pearson/Spearman's correlation coefficient (r) and receiver operating characteristic (ROC) curves were used to evaluate the ability of tPSA and fPSA to predict PV. The correlation coefficient between tPSA and PV in the PSA <2.5 ng ml−1 cohort (r = 0.422; P < 0.001) was markedly higher than those of the cohorts with PSA levels of 2.5–3.9 ng ml−1, 4.0–9.9 ng ml−1, and 2.5–9.9 ng ml−1 (r = 0.114, 0.167, and 0.264, respectively; all P ≤ 0.001), while fPSA levels did not differ significantly among different PSA groups. Area under ROC curve (AUC) analyses revealed that the performance of fPSA in predicting PV ≥40 ml (AUC: 0.694, 0.714, and 0.727) was better than that of tPSA (AUC = 0.545, 0.561, and 0.611) in men with PSA levels of 2.5–3.9 ng ml−1, 4.0–9.9 ng ml−1, and 2.5–9.9 ng ml−1, respectively, but not at PSA levels of <2.5 ng ml−1 (AUC: 0.713 vs 0.720). These findings suggest that the relationship between tPSA and PV may vary with PSA level and that fPSA is more powerful at predicting PV only in the ''gray zone'' (PSA levels of 2.5–9.9 ng ml−1), but its performance was similar to that of tPSA at PSA levels of <2.5 ng ml−1.


[FULL TEXT] [PDF]
Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Huang MP
    -  Tang P
    -  Klein CS
    -  Wei XH
    -  Du W
    -  Fu JG
    -  Huang TH
    -  Chen H
    -  Xie KJ
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed241    
    PDF Downloaded10    

Recommend this journal