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Age-related changes for the predictors of benign prostatic hyperplasia in Chinese men aged 40 years or older


1 Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China
2 Department of Urology, The Third People's Hospital of Zhengzhou, Zhengzhou 450000, China

Correspondence Address:
Wei-Dong Zhang,
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001
China
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aja202223

A cross-sectional study was conducted to estimate the age-stratified normal levels and age-related changes in the risk predictors of benign prostatic hyperplasia (BPH) progression. A total of 4706 male participants aged 40 years or older in Zhengzhou (China) were enrolled. The values of the International Prostate Symptom Score (IPSS), prostate-specific antigen (PSA), prostate volume (PV), and postvoid residual urine volume (PVR) significantly increased with age. Nonlinear relationships between age and IPSS scores ≥8 (P for nonlinearity = 0.046), PSA level ≥1.6 ng ml–1, PV ≥31 ml, or PVR ≥39 ml (all P for nonlinearity <0.001) were observed. After the age of 61 years, the risk indicators related to BPH progression were positively correlated with age (odds ratio [OR] >1), regardless of the predictors of the IPSS score, PSA level, PV, or PVR; and the OR values increased gradually. Therefore, after the age of 61 years, the risk predictors related to BPH progression were positively correlated with age.


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    -  Shao WH
    -  Zheng CF
    -  Ge YC
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