ORIGINAL ARTICLE
Year : 2022  |  Volume : 24  |  Issue : 6  |  Page : 628-632

Quantitative assessment of the aging corpus cavernosum by shear wave elastography


1 Department of Ultrasonography, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China Department of Ultrasonography, Shaanxi Province Cancer Hospital, Xi'an 710061, China Department of Urology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China

Correspondence Address:
Li-Tao Ruan
Department of Ultrasonography, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061
China
Lin Yang
Department of Urology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aja2021119

Rights and Permissions

We wanted to determine whether shear wave elastography (SWE) could be used to evaluate the aging degree of the corpus cavernosum (CC) and to identify the histological basis of changes in SWE measurements during the aging process. We performed a cross-sectional study enrolling healthy participants of different ages. We measured the Young's modulus (YM) of the penile CCs by SWE and assessed erectile function using the International Index of Erectile Function-5 (IIEF-5). Histological investigation was performed in surgically resected penile specimens from a separate group of patients to examine the smooth muscle and collagen content of the CCs. Furthermore, we measured the YM, erectile function, smooth muscle, and collagen content of the CCs in different age groups of rats. Finally, we enrolled 210 male volunteers in this study. The YM of the CC (CCYM) was positively correlated with age (r = 0.949, P < 0.01) and negatively correlated with erectile function (r = −0.843, P < 0.01). Histological examinations showed that CCs had increased collagen content but decreased smooth muscle content with increased age. The same positive correlation between CCYM and age was also observed in the animal study. In addition, the animal study showed that older rats, with increased CCYM and decreased erectile function, had lower smooth muscle content and higher collagen content. SWE can noninvasively and quantitatively evaluate the aging degree of the CC. Increased collagen content and decreased smooth muscle content might be the histological basis for the effect of aging on the CC and the increase in its YM.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1200    
    Printed146    
    Emailed0    
    PDF Downloaded108    
    Comments [Add]    

Recommend this journal