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Is serum sex hormone-binding globulin a dominant risk factor for metabolic syndrome?
Yi-Hong Yang1, Ming-Jia Zhao2, Shan-Jie Zhou3, Wen-Hong Lu4, Xiao-Wei Liang4, Cheng-Liang Xiong5, Chang-Chun Wan6, Xue-Jun Shang7, Yi-Qun Gu1
1 Graduate School of Peking Union Medical College, Beijing 100730; National Health and Family Planning Key Laboratory of Male Reproductive Health, Department of Male Clinical Research, National Research Institute for Family Planning, Beijing 100081, China
2 Department of Reproduction and Genetics, Maternity and Child Health Care Hospital, Tangshan 063000, China
3 Tianjin United Family Hospital and Clinics, Tianjin 300221, China
4 National Health and Family Planning Key Laboratory of Male Reproductive Health, Department of Male Clinical Research, National Research Institute for Family Planning, Beijing 100081, China
5 Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
6 People's Hospital of Jinhu, Huaian 211600, China
7 Department of Andrology, Nanjing General Hospital of Nanjing Command, PLA, Nanjing 210002, China
Correspondence Address:
Xue-Jun Shang
Department of Andrology, Nanjing General Hospital of Nanjing Command, PLA, Nanjing 210002
China
Yi-Qun Gu
Graduate School of Peking Union Medical College, Beijing 100730; National Health and Family Planning Key Laboratory of Male Reproductive Health, Department of Male Clinical Research, National Research Institute for Family Planning, Beijing 100081
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1008-682X.150845
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This multi-center, cross-sectional study investigated the association between serum testosterone (T) levels, serum sex hormone-binding globulin (SHBG) levels, and the risk of metabolic syndrome (MS) in 3332 adult Chinese men. The prevalence of MS was 34.7%, and men with MS had lower serum levels of total T (TT) and SHBG than those without MS (P < 0.001). There was no significant difference in serum free T (FT) levels between subjects with and without MS (P = 0.627). In logistic regression analysis, the association between MS and serum SHBG levels persisted after adjusting for age, body mass index (BMI), smoking and drinking status, and serum TT (odds ratio [OR] 0.962, 95% confidence interval [95% CI] 0.954−0.969, P< 0.01). However, the association between serum TT level and the risk of MS was weak after adjusting for age, BMI, SHBG level, and smoking and drinking status (OR 0.981, 95% CI 0.960−1.007). Our study reveals that both serum TT and SHBG levels, but not serum FT, are inversely associated with the prevalence of MS and that serum SHBG is an independent and dominant risk factor for MS. |
