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INVITED REVIEW
Year : 2015  |  Volume : 17  |  Issue : 6  |  Page : 942-947

Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology

Li-Li Liu1, Hua Xian2, Jing-Chen Cao3, Chong Zhang3, Yong-Hui Zhang3, Miao-Miao Chen3, Yi Qian1, Ming Jiang4
1 Laboratory of Nuclear Receptors and Cancer Research, Basic Medical Research Center, Nantong University School of Medicine; Department of Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
2 Department of Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
3 Laboratory of Nuclear Receptors and Cancer Research, Basic Medical Research Center, Nantong University School of Medicine, Nantong, Jiangsu, China
4 Laboratory of Nuclear Receptors and Cancer Research, Basic Medical Research Center, Nantong University School of Medicine, Nantong, Jiangsu, China; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA

Correspondence Address:
Ming Jiang
Laboratory of Nuclear Receptors and Cancer Research, Basic Medical Research Center, Nantong University School of Medicine, Nantong, Jiangsu, China; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.150253

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Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the PPARs, which are transcription factors of the steroid receptor superfamily. PPARγ acts as an important molecule for regulating energy homeostasis, modulates the hypothalamic-pituitary-gonadal (HPG) axis, and is reciprocally regulated by HPG. In the human, PPARγ protein is highly expressed in ejaculated spermatozoa, implying a possible role of PPARγ signaling in regulating sperm energy dissipation. PPARγ protein is also expressed in Sertoli cells and germ cells (spermatocytes). Its activation can be induced during capacitation and the acrosome reaction. This mini-review will focus on how PPARγ signaling may affect fertility and sperm quality and the potential reversibility of these adverse effects.


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