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INVITED REVIEW
Year : 2015  |  Volume : 17  |  Issue : 5  |  Page : 742-748

Posttesticular sperm maturation, infertility, and hypercholesterolemia

Marjorie Whitfield1, Xavier Pollet-Villard2, Rachel Levy2, Joël R Drevet1, Fabrice Saez1
1 Team "Mechanisms of post testicular infertility", Génétique Reproduction et Développement, UMR CNRS 6293, INSERM U1103, Clermont Université, 24 Avenue des Landais, BP80026, 63171 Aubière Cedex, France
2 Service d'Histologie-Embryologie-Cytogénétique CECOS, Hôpital Jean Verdier (AP-HP), Avenue du 14 Juillet, 93143 Bondy; Service de Médecine de la Reproduction, Hôpital Tenon (AP-HP), 4 Rue de la Chine, 75020, Paris; Unité de Recherche en Epidémiologie Nutritionnelle, INSERM U557, INRA, CNAM, Université Paris 13, CRNH IdF, 93017 Bobigny, France

Correspondence Address:
Joël R Drevet
Team "Mechanisms of post testicular infertility", Génétique Reproduction et Développement, UMR CNRS 6293, INSERM U1103, Clermont Université, 24 Avenue des Landais, BP80026, 63171 Aubière Cedex
France
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.155536

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Cholesterol is a key molecule in the mammalian physiology of especial particular importance for the reproductive system as it is the common precursor for steroid hormone synthesis. Cholesterol is also a recognized modulator of sperm functions, not only at the level of gametogenesis. Cholesterol homeostasis regulation is crucial for posttesticular sperm maturation, and imbalanced cholesterol levels may particularly affect these posttesticular events. Metabolic lipid disorders (dyslipidemia) affect male fertility but are most of the time studied from the angle of endocrine/testicular consequences. This review will focus on the deleterious effects of a particular dyslipidemia, i.e., hypercholesterolemia, on posttesticular maturation of mammalian spermatozoa.


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