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Year : 2015  |  Volume : 17  |  Issue : 3  |  Page : 443

Editorial: A discussion about "sperm factor" involved into egg activation

Asian Journal of Andrology Editorial Office, Shanghai, China

Date of Web Publication30-Apr-2015

Correspondence Address:
Dan-Qing Ren
Asian Journal of Andrology Editorial Office, Shanghai
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1008-682X.145429

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How to cite this article:
Ren DQ. Editorial: A discussion about "sperm factor" involved into egg activation. Asian J Androl 2015;17:443

How to cite this URL:
Ren DQ. Editorial: A discussion about "sperm factor" involved into egg activation. Asian J Androl [serial online] 2015 [cited 2022 Sep 25];17:443. Available from:

It is well-known that controversies and questions exist in all fields of knowledge. Beyond doubt, they play an important role in driving the development of science and technology. It is, therefore, not surprising that controversies also arise in the area of reproductive biology, and it is our belief that thorough testing of alternative hypotheses will accelerate our understanding of this field. One of the open questions in reproduction is how the sperm activate the egg during fertilization. Over the years, different mechanisms have been proposed, which led to multiple discussions. Although today, there is a general consensus that egg activation involves the release of a "sperm factor" that follows gamete fusion, the identity of the molecule involves in this process is still under discussion. Recently, Asian Journal of Andrology got three successive commentary articles which target the problem of the molecular nature of the "sperm factor." Is it PAWP, PLC zeta, or both? Are other molecules also involved? These articles present alternative views and two of them are written, respectively, by authors involved in the original discovery of PLCzeta and PAWP. Altogether, these articles summarized pros and cons of each hypothesis and present criteria to be followed in future research on this field. We sincerely hope that this discussion could facilitate communication between the groups, that new avenues of research could be inspired during this scientific discussion, and that this scientific area and our readers will benefit from this type of discussion.


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