ORIGINAL ARTICLE
Ahead of Print

Cavernous nerve reconstruction with autologous vein graft and platelet-derived growth factors


 Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China

Correspondence Address:
Shi-Wen Li,
Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan 430071
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None

In this study, we investigated the feasibility of using autologous vein graft and platelet-derived growth factors to bridge transected cavernous nerve in a rat model. A short defect in the bilateral cavernous nerve was created and repaired with vein graft from the right jugular vein or vein graft plus platelet-derived growth factors. The 32 rats were divided into four groups, namely Group 1 - no repair as a negative control, Group 2 - vein graft alone, Group 3 - vein graft plus platelet-derived growth factors, and Group 4 - sham operation as a positive control. We evaluated nerve regeneration and functional recovery using retrograde tracing study with FluoroGold, Toluidine blue staining of cavernous nerve, and the intracavernous pressure at 3 months. Three months after surgery, rich FluoroGold-positive cells were observed in the sham and vein graft plus platelet-derived growth factors group, but very few were found in the no repair group. The number of myelinated axons of regenerated cavernous nerve and intracavernous pressure were increased obviously in the two vein graft groups, especially in the vein graft plus platelet-derived growth factors group. These findings confirm the feasibility of using autologous vein as guides for cavernous nerve regeneration, and the regeneration can be further enhanced when the vein is filled with platelet-derived growth factors.


[FULL TEXT] [PDF]
Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Ding XG
    -  Li SW
    -  Zheng XM
    -  Wang XH
    -  Luo Y
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed738    
    PDF Downloaded65    

Recommend this journal